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Read about blood sugar, cholesterol, homemade cosmetics, find salicylate free strategies and more.

Salicylate free Supplements

Salicylate Free Cosmetics

Reactive Hypoglycemia may be caused by food intolerance, including salicylates in food

Salicylates in Foods - Teas are relatively high in salicylates

Aspirin sensitivity and urticaria

Symptomatic patients with celiac disease who are on gluten free diet sometimes have a salicylate intolerance



Salicylate Intolerance Links and information

Some individuals feel that they have a salicylate intolerance or allergy that causes them serious health problems. Some have reported a wide range of symptoms that they feel are alleviated by strict avoidance of salicylates in food and other products.

WebMD states that salicylate sensitivity symptoms vary but may include  a life-threatening reaction involving a severe drop in blood pressure, loss of consciousness, and organ system failure.  Other possible symptoms are:

  • Asthma-like symptoms, such as trouble breathing and wheezing
  • Headaches
  • Nasal congestion
  • Changes in skin color
  • Itching, skin rash or hives
  • Swelling of the hands, feet, and face
  • Stomach pain

According to the FDA, 5% of the population is sensitive to salicylates.  Symptoms such as itching, broncho-spasm and localized swelling that can be life-threatening can occur, even in those with no prior history of sensitivity to salicylates.  US FDA/CFSAN

It is well known and accepted that Reyes Syndrome is connected to ingestion of medications with salicylates and that many with asthma are highly sensitive and often unable to tolerate medications with salicylates.  However there has been little if any exploration of salicylate allergy or intolerance, even in those with known health problems that have a connection to salicylates such as Reyes syndrome and asthma.

There are those, including some in the medical community that feel that ADHD and ADD may be related to ingestion of salicylates.  To further explore that relationship, please see the
Feingold Association homepage

Of particular interest to those with Fibromyalgia, Chronic Fatigue Syndrome and similar illnesses is that most of the symptoms that are mentioned for salicylate intolerance are symptoms that are associated with Fibromyalgia Syndrome (FMS)  and Chronic Fatigue And Immune Dysfunction Syndrome (CFIDS).  It seems possible that some who have been diagnosed with FMS or CFIDS may have a problem with salilcylates.

Interestingly enough, many with FMS and CFIDS have had improvement in their condition by following the
guaifenesin protocol, part of which requires that one avoid topical and concentrated salicylates but not salicylates in food.  In the guaifenesin protocol, the avoidance of salicylates is required because salicylates block the medication (guaifenesin) from working properly, not because of a perceived problem with a salicylate intolerance. It does seem possible that there are a subset of individuals who show improvement because they are avoiding salicylates.  These individuals may show even more improvement if they were to change their diet to avoid salicylates. For more information see: Your complete guide to Salicylate sensitivity

Salicylates and Blood Sugar
Salicylate is listed as a drug that may be related to hypoglycemia. 
eMedicine - Hypoglycemia : Article by Frank Smeeks, MD, FAAEM 

Aspirin is a salicylate.  Doses of salicylates that are commonly used to treat rheumatoid arthritis (4-6 grams per day) may induce hypoglycemia in both non-diabetic and diabetic adults and may reduce insulin requirements in type 1 diabetes. 3

People with impaired kidney function should be careful in their use of salicylates.  A case of hypoglycemia was reported in the Archives of Internal Medicine to be caused by topical salicylate use in an elderly man with reduced kidney function.4

A salicylate free diet is recommended by these  allergy specialists for people who are having difficulty getting rid of hypoglycemia.
Reactive Hypoglycemia may be caused by food intolerance, including salicylates in food

According to this research, salicylate might be considered in the therapy of type 2 diabetes someday.
Prevention of fat-induced insulin resistance by salicylate

Salicylates and Contact Dermatitis
One study of 6 patients with contact dermatitis of the lips determined that 5 of the 6 patients were allergic to phenyl salicylate.1  It was noted at St. Luke's Hospital in the United Kingdom that a 2 year old had urticaria that did not respond to antihistamine therapy. It was found that she was using a topical salicylate preparation that was regularly being applied to her pacifier. Her urticaria cleared and has not recurred once they stopped the topical.2  There are many other accounts of these types of reactions to topical salicylates.

Salicylates and Bacteria
Salicylates are used by plants to fend off bacteria, viruses and other pests.  Salicylates do have an affect on bacteria and in fact, cause some bacteria to become resistant to certain antibiotics.
The effects of salicylate on bacteria

Salicylate induction of phenotypic resistance to quinolones in Serratia marcescens -- Berlanga and Viñas 46 (2): 279 -- Journal of Antimicrobial Chemotherapy

Salicylate Reduces Susceptibility of Mycobacterium tuberculosis to Multiple Antituberculosis Drugs -- Schaller et al. 46 (8): 2636 -- Antimicrobial Agents and Chemotherapy

Hopefully, more studies will be forthcoming that will help determine the extent of salicylate intolerance and it's affect on health.  Following are links that may help you to further explore this subject.

Salicylate intolerance in diseases of the lower gastrointestinal tract
Patients with chronic active disease who have inflammatory bowel disease and food allergies should be  evaluated for salicylate intolerance.5

Entrez PubMed  "Salicylate sensitivity in Children reported to respond to salicylate exclusion"

Symptoms of Additive/Salicylate Sensitivity

Your complete guide to Salicylate sensitivity

WebMD Salicylate Allergy

National Reye's Syndrome Foundation Home Page

eMedicine - Toxicity, Salicylate : Article by Lance W Kreplick, MD, MMM

Salicylates, Amines and Glutamate booklet introduction - RPAH Allergy Unit

Salicylate (Aspirin) Ingestion/California Poison Control
"Salicylates directly or indirectly affect most organ systems in the body by uncoupling oxidative phosphorylation, inhibiting Krebs cycle enzymes, and inhibiting amino acid synthesis."

Sal-FreeTM Centre - Various Data Bases & Information regarding salicylates
Lots of useful information about salicylates as it applies to the guaifenesin protocol

Plant Choices - Phytochemeco Databases

ADHD Diet - Feingold Association - Feingold diet for ADHD

Salicylate Free Diet

Diets for Special Problems - Hives and salicylates

Salicylate List for foods

Food Salicylate Content List

Salicylates in Food - Swain Study

1.  Calnan CD, Cronin E, Rycroft RJ., "Allergy to phenyl salicylate.", Contact Dermatitis. 1981 Jul;7(4):208-11.
Entrez PubMed

2.  Wright AL, Minford A., "Urticaria and hidden salicylates.", Pediatr Dermatol. 1999 Nov-Dec;16(6):463-
Entrez PubMed

3. Manjula K. Pandit; John Burke; Anthony B. Gustafson; Anil Minocha; and Alan N. Peiris, "Drug-induced Disorders of Glucose Tolerance", annals of internal medicine:1 April 1993 | Volume 118 Issue 7 | Pages 529-539
Drug-induced Disorders of Glucose Tolerance -- Pandit et al. 118 (7): 529 -- Annals of Internal Medicine

4.  R. Raschke, P. A. Arnold-Capell, R. Richeson and S. C. Curry, "Refractory hypoglycemia secondary to topical salicylate intoxication", Archives of Internal medicine Vol. 151 No. 3, March 1, 1991
Arch Intern Med -- Abstract: Refractory hypoglycemia secondary to topical salicylate intoxication, March 1, 1991, Raschke et al. 151 (3): 591

5.   Raithel M, Baenkler HW, Naegel A, Buchwald F, Schultis HW, Backhaus B, Kimpel S, Koch H, Mach K, Hahn EG, Konturek PC., "Significance of salicylate intolerance in diseases of the lower gastrointestinal tract.", J Physiol Pharmacol. 2005 Sep;56 Suppl 5:89-102.
Significance of salicylate intolerance in diseases of the lower gastrointestinal tract.

The information presented here is not intended to diagnose, treat, cure or prevent any disease. We do not accept any responsibility for the use or misuse of any of the information contained herein.


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