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PDR Health on Malic Acid

Immunesupport.com article on Malic Acid and Fibromyalgia
 


 Malic Acid: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References


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Malic Acid and Magnesium for Fibromyalgia and Chronic Pain Syndrome

 

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Malic Acid

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Malic Acid, also known as apple acid, hydroxybutanedioic acid and hydroxysuccinic acid is an alpha-hydroxy organic acid that occurs naturally in a wide variety of unripe fruit, such as apples, cherries, and tomatoes.  It is used as a flavoring and in the aging of wine.  Malic Acid is also produced in the body.  It is naturally synthesized through the citric acid cycle.

Malic Acid plays a role in the process of deriving adenosine triphosphate (ATP, the energy currency that runs the body) from food.  It is essential in the production of energy and helps remove high levels of phosphorous and aluminum from the body.

Candida or Fungal infections
Tartaric Acid is an analog of Malic Acid and inhibits the production of Malic Acid.  Tartaric Acid is a muscle toxin that is produced by fungal and yeast metabolites.  Tartaric Acid is thought to be toxic because it is a known inhibitor of the Krebs cycle enzyme fumarase which produces Malic Acid from fumaric acid. In other words, Tartaric Acid will cause a person to become deficient in Malic Acid which is a critical component needed to make energy from food.   Supplements of Malic Acid are thought to be able to overcome the toxic effects of Tartaric Acid by supplying deficient Malic Acid.

Fibromyalgia
Fibromyalgia patients may receive benefit from treatment with Malic Acid.1  Malic Acid helps keep Tartaric Acid (a muscle toxin) in check.  Tartaric Acid is often extremely elevated in Fibromyalgia patients.  Muscle weakness may be related to elevated levels of Tartaric Acid.

In some studies, subjective improvement in pain was observed within 48 hours of supplementation with 1200-2400 mg. of Malic Acid.   The improvement was lost following the discontinuation of Malic Acid for 48 hours.

Fifty percent of patients with fibromyalgia suffer from hypoglycemia (low blood sugar). This may in part be due to the inhibition of the Krebs cycle by Tartaric Acid.

Hypoglycemia

In addition to the inhibition of energy production, Tartaric Acid prevents the production of Malic Acid, which is a key intermediate in the production of glucose in the process of gluconeogenisis, the principal fuel for the brain.  If sufficient Malic Acid cannot be produced, the body cannot produce the sugar glucose which is the main fuel for the brain. The person with hypoglycemia feels weak and their thinking is foggy because there is insufficient fuel for their brain.



Malic Acid and Energy
Malic Acid has an oxygen sparing effect and there are a number of indications that Malic Acid allows the body to produce ATP even under low oxygen (hypoxic) conditions. Malate, a molecule that contains Malic Acid falls significantly in concentration during exhaustive physical activity. By supplementing Malic Acid in the diet, flexibility to use aerobic and anaerobic energy sources can be enhanced and energy production can be boosted.

Detoxifying with Malic Acid
Malic Acid protects against the toxic effects of aluminum and phosphorous. Because of its affinity for phosphate groups, aluminum blocks the utilization of phosphate for ATP (energy) synthesis. Adequate Malic Acid can prevent this toxic effect from occurring. Malic Acid is one of the most potent chelators of aluminum and was the most effective of several chelators tested at reducing aluminum levels in the brain. Treatment with Malic Acid has been shown to greatly increase the fecal and urinary excretion of aluminum and reduce the concentration of aluminum found in various organs and tissues.
The Team Value Of Magnesium And Malic Acid

Oral Hygiene
Malic Acid stimulates the production of saliva, which reduces the number of harmful bacteria circulating in your mouth, teeth and gums. It acts as an antiseptic too, which also helps to ensure that germs in the mouth are kept to a minimum and considerably reduces the risk of infection.2

For these reasons, Malic Acid is commonly used as an ingredient in mouthwashes and toothpastes.


Alzheimers
Although controversial, high aluminum levels in the brain have long been considered a possible factor in the development of alzheimer's disease.  One recent medical article concluded that based on current literature, the neurotoxic effects of aluminium are beyond any doubt, and aluminium as a factor in Alzheimer's Disease cannot be discarded.2


WARNINGS:
Because of lack of long-term safety studies, supplementary Malic Acid should be avoided by pregnant women and lactating mothers
 


Before taking any supplements, consult with your health care provider. The information presented here is not intended to diagnose, treat, cure or prevent any disease. We do not accept any responsibility for the use or misuse of any of the information contained herein.


References

2. Gupta VB, Anitha S, Hegde ML, Zecca L, Garruto RM, Ravid R, Shankar SK, Stein R, Shanmugavelu P, Jagannatha Rao KS., "Aluminium in Alzheimer's disease: are we still at a crossroad?", Cell Mol Life Sci. 2005 Jan;62(2):143-58.
Aluminium in Alzheimer's disease: are we still at a crossroad?

3.  Domingo JL, Gomez M, Llobet JM, Corbella J., "Comparative effects of several chelating agents on the toxicity, distribution and excretion of aluminium.", Hum Toxicol. 1988 May;7(3):259-62.
Comparative effects of several chelating agents on the toxicity, distribution and excretion of aluminium.
Malic Acid
 

*Sal-FreeTM and *Sal-SafeTM are trademarked terms and are used with the permission of Tesa Marcon of the Guai-Support Group


 

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