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Malic Acid
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Sal-FreeTM Malic Acid
Malic Acid, also known as apple acid, hydroxybutanedioic acid and
hydroxysuccinic acid is an alpha-hydroxy organic acid that occurs naturally
in a wide variety of unripe fruit, such as apples, cherries, and tomatoes.
It is used as a flavoring and in the aging of wine. Malic Acid is
also produced in the body. It is naturally synthesized through the
citric acid cycle.
Malic Acid plays a role in the process of deriving
adenosine triphosphate (ATP, the energy currency that runs the body) from
food. It is essential in the
production of energy and helps remove high levels of phosphorous and
aluminum from the body.
Candida or Fungal infections
Tartaric Acid is an analog of Malic Acid and inhibits the production of
Malic Acid. Tartaric Acid is a muscle toxin that is produced by
fungal and yeast metabolites. Tartaric Acid is thought to be toxic
because it is a known inhibitor of the Krebs cycle enzyme fumarase which
produces Malic Acid from fumaric acid. In other words, Tartaric Acid will
cause a person to become deficient in Malic Acid which is a critical
component needed to make energy from food. Supplements of
Malic Acid are thought to be able to overcome the toxic effects of
Tartaric Acid by supplying deficient Malic Acid.
Fibromyalgia
Fibromyalgia patients may receive benefit from treatment
with Malic Acid.1 Malic Acid helps keep Tartaric Acid (a
muscle toxin) in check. Tartaric Acid is often extremely elevated in Fibromyalgia patients.
Muscle weakness may be related to elevated levels of Tartaric Acid.
In some studies, subjective improvement in pain was observed within 48
hours of supplementation with 1200-2400 mg. of Malic Acid. The
improvement was lost following the discontinuation of Malic Acid for 48
hours.
Fifty percent of patients with fibromyalgia suffer from hypoglycemia
(low blood sugar). This may in part be due to the inhibition of the Krebs
cycle by Tartaric Acid.
Hypoglycemia
In addition
to the inhibition of energy production, Tartaric Acid prevents the
production of Malic Acid, which is a key intermediate in the production of
glucose in the process of gluconeogenisis, the principal fuel for the
brain. If sufficient Malic Acid
cannot be produced, the body cannot produce the sugar glucose which is the
main fuel for the brain. The person with hypoglycemia feels weak and their
thinking is foggy because there is insufficient fuel for their brain.
Malic Acid and Energy
Malic Acid has an oxygen sparing effect and there are a number of
indications that Malic Acid allows the body to produce ATP even under low
oxygen (hypoxic) conditions. Malate, a molecule that contains Malic Acid
falls significantly in concentration during exhaustive physical activity.
By supplementing Malic Acid in the diet, flexibility to use aerobic and
anaerobic energy sources can be enhanced and energy production can be
boosted.
Detoxifying with Malic Acid
Malic Acid protects against the toxic effects of aluminum and
phosphorous. Because of its affinity for phosphate groups, aluminum blocks
the utilization of phosphate for ATP (energy) synthesis. Adequate Malic
Acid can prevent this toxic effect from occurring. Malic Acid is one of
the most potent chelators of aluminum and was the most effective of
several chelators tested at reducing aluminum levels in the brain.
Treatment with Malic Acid has been shown to greatly increase the fecal and
urinary excretion of aluminum and reduce the concentration of aluminum
found in various organs and tissues.
The Team Value
Of Magnesium And Malic Acid
Oral Hygiene
Malic Acid stimulates the production of saliva, which reduces the number of
harmful bacteria circulating in your mouth, teeth and gums. It acts as an
antiseptic too, which also helps to ensure that germs in the mouth are
kept to a minimum and considerably reduces the risk of infection.2
For these reasons, Malic Acid is commonly used as an ingredient in
mouthwashes and toothpastes.
Alzheimers
Although controversial, high aluminum levels in the brain have long been considered
a possible factor in the development of alzheimer's disease. One
recent medical article concluded that based on current literature, the
neurotoxic effects of aluminium are beyond any doubt, and aluminium as a
factor in Alzheimer's Disease cannot be discarded.2
WARNINGS:
Because of lack of long-term safety studies, supplementary Malic
Acid should be avoided by pregnant women and lactating mothers
Before taking any supplements, consult with
your health care provider. The information presented here is not intended to
diagnose, treat, cure or prevent any disease. We do not accept any
responsibility for the use or misuse of any of the information contained
herein.
References
2. Gupta VB, Anitha S, Hegde ML, Zecca L, Garruto RM, Ravid R, Shankar SK,
Stein R, Shanmugavelu P, Jagannatha Rao KS., "Aluminium in Alzheimer's
disease: are we still at a crossroad?", Cell Mol Life Sci. 2005
Jan;62(2):143-58.
Aluminium in Alzheimer's disease: are we still at a crossroad?
3. Domingo JL, Gomez M, Llobet JM, Corbella J., "Comparative effects
of several chelating agents on the toxicity, distribution and excretion of
aluminium.", Hum Toxicol. 1988 May;7(3):259-62.
Comparative effects of several chelating agents on the
toxicity, distribution and excretion of aluminium.
Malic Acid
*Sal-FreeTM
and *Sal-SafeTM
are trademarked terms and are used with the permission of
Tesa Marcon of the
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