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MedlinePlus Medical Encyclopedia: Mouth sores
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From Amazon.com - Persistent aphthous ulcers are often the canary in a diagnostic coal mine.(Clinical Rounds) : An article from: Skin & Allergy News
Canker Sores - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Herpes Simplex (Cold Sores) - health information from McKinley health center
 UlcerEase Anesthetic Mouth Rinse
Helpful for the pain of canker sores.
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Helpful for cold sores.
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Nature's Way Novitra Cold Sore Cream
Helpful for cold sores.
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Helpful for cold sores.
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Pascalite Bentonite Healing Powder - 16 oz. powder in Flip top bottle
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Mix with water to form a thick paste and apply as a poultice for cold sores.
 Pure Lip Remedy, Step One in The Cold Sore Solution
Not to be used by those who must avoid salicylates!
 Aquaphor Healing Ointment
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Mouth sores
Canker Sores and Cold Sores
Canker sores are non-contagious
ulcers (also called aphthous stomatitis or aphthous ulcers) that form inside
the mouth. Cold sores are different than
canker sores in that cold sores are highly contagious blisters that usually
form on the outside of the mouth and on the gums. Cold sores are
caused by the herpes simplex virus whereas canker sores are thought to occur
for a variety of reasons.
Canker Sores
Canker
sores are single or clustered ulcers that can occur anywhere inside the
mouth. They are painful and last anywhere from 7-21 days, often
recurring in some people. It is estimated that 20%-25% of the
population get canker sores.
Canker sores can be associated with a systemic disease, such as Behçet
syndrome or inflammatory bowel disease. In addition, canker sores can be caused by nutritional deficiencies, food allergies
(particularly gluten sensitivity), stress or local trauma to the mouth such
as that caused by biting the inside of the mouth or using a hard toothbrush.
H. Pylori may also be a factor.
Canker Sores and Nutritional Deficiencies
Many studies indicate that nutritional deficiencies are
much more common among recurrent canker sore sufferers than the general
population and that treatment of these deficiencies can lead to significant
reduction or a complete remission.
-
Vitamin B-1 (Thiamine)
Several studies have shown a relationship between a
Vitamin B-1 deficiency and recurrent canker sores. One study found
that low levels of B-1 were found in 49 of 70 people with recurring
canker sores.8 Patients who had a B complex deficiency
of one or more of the following: B-1, B-2, or B-6 received significant
improvement and in some cases, total remission when treated for the deficiency.9.11
Another study concluded that Vitamin B-1, along with other nutrients,
may be deficient.5
-
B-12 deficiency
As a result of studies, it is well known that a vitamin B-12 deficiency
is often found in people with recurring canker sores.1,4,7
It seems reasonable that all patients with recurring canker sores should
be evaluated for vitamin B12 deficiency.6
-
B-2 deficiency
Patients who had a B complex deficiency of one or more of the
following: B-1, B-2, or B-6, received significant improvement when treated for the deficiency.9
-
B-6 deficiency
Patients who had a B complex deficiency of one or more of the
following: B-1, B-2, or B-6 received significant improvement in their
recurring canker sores when treated for the deficiency.9
-
Calcium
One study hypothesized that not only iron and vitamin B1 might be
deficient in patients with recurring canker sores, but calcium and
vitamin C may also be deficient. 5
-
Folic Acid (Folate)
Studies show that people with recurrent canker sores are
more likely to have a folic acid deficiency than the general
poplulation.4,7 Some patients received full remission
when treated for their deficiency.11
-
Iron
It is well known that Iron is found to be deficient in
some people with recurrent canker sores.7 Some patients
received full remission when treated for their deficiency.11
-
Vitamin C
One study hypothesized that not only iron and vitamin B1
might be deficient in patients with recurring canker sores, but calcium
and vitamin C may also be deficient. 5
Canker Sores and Allergies or Sensitivities
It has been shown that allergies play a role in some cases of
recurrent canker sores.13,14,15. A study that shows elevated
levels of allergic white blood cells and antibodies confirms an association.16
In one small study (12 participants), 5 of the 12 who followed a strict
elimination diet for food allergies received marked improvement or remission
of recurrent canker sores.13
Some people who were specifically screened for celiac (an inflammatory disease of the bowel caused
by gluten proteins which are contained in wheat and other grains), and found
to be negative for celiac, received relief of recurring canker sores
by avoiding gluten due to a gluten sensitivity.10
Canker Sores and Stress
Stress is said to often be a factor
in recurring canker sores. This could be related to a B vitamin
deficiency (stress often depletes B vitamins) or a break down of the immune
system.
H.Pylori
Out of a group of 48 patients with recurring canker sores, 34 were diagnosed with H.Pylori. H.Pylori
was eradicated and in a 6-12 month follow-up, it was discovered that
those who had been treated for H.Pylori showed a remarkable improvement
(62.5%) in the recurrence of their canker sores as well as in symptom intensity.
After the eradication treatment, the periods between recurrence
in patients who had become negative were statistically significantly
longer compared with those before treatment. The study concluded
that their results may show a correlation between canker sores and
H.Pylori.2 According to an article in the Journal of
The Canadian Dental Association, H.Pylori is present in dental plaque and
may be a cofactor in the recurrence of canker sores.3
Supplements found to be helpful for canker sores
Acidophilus/Probiotics
Acidophilus/probiotics
Products Products
Acidophilus/probiotics
Sal-FreeTM only
Lysine
L-lysine
Products
L-lysine
Sal-FreeTM only
B-12
B-12 Products
B-12 Sal-FreeTM only
B-1
B-1 Products
B-1 Sal-FreeTM only
B-2
B-2 Products
B-2 Sal-FreeTM only
B-6
B-6 Products
B-6 Sal-FreeTM only
B-5 (pantothenic acid)
B5 (Pantothenic Acid) Products
B-5 (Pantothenic Acid) Sal-FreeTM only
Calcium
Calcium Products
Calcium Sal-FreeTM Only
Folic Acid
Folic Acid Products
Folic Acid Sal-FreeTM only
Iron
Iron products
Iron Sal-FreeTM only
Mineral Complex
Mineral Complex Products
Mineral Complex Sal-FreeTM Only
Vitamin C
Vitamin C Products
Vitamin C Sal-FreeTM Only
Zinc lozenges
Cold Sores
Cold sores, also called fever blisters are common and very contagious. They are
caused by the herpes simplex virus (HSV-1). Studies show that between
30%-60% of children carry the virus by age 2. Typically tenderness,
tingling, or burning appear before the lesion appears. Herpes lesions
begin as blisters and then crust over.
Supplements shown to be helpful for cold sores.
Acidophilus
Acidophilus/probiotics
Products Products
Acidophilus/probiotics
Sal-FreeTM only
Calcium and Magnesium
Calcium and Magnesium Products
Magnesium and Calcium Sal-FreeTM Only
Colloidal Silver
Colloidal Silver Products
Colloidal Silver Sal-FreeTM Only
Essential Fatty Acids (EFA's such as fish oil)
Fish Oil Products
Fish Oil Sal-FreeTM Only
L-lysine
L-lysine
Products
L-lysine
Sal-FreeTM only
Vitamin C
Vitamin C Products
Vitamin C Sal-FreeTM Only
Zinc lozenges
Styptic pencil can be helpful in treating a cold sore.
Apply the pencil immediately after you notice the sore beginning to
form. Make sure to dry the area where the sore is in order for the
pencil to be effective. You may need to apply it several times.
References
1. Piskin S, Sayan C, Durukan N, Senol M.,
"Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent
aphthous stomatitis.", J Eur Acad Dermatol Venereol. 2002 Jan;16(1):66-7
Entrez Pubmed
2. Albanidou-Farmaki E, Giannoulis L, Markopoulos A, Fotiades S,
Aggouridaki X, Farmakis K, Papanayotou P., "Outcome following treatment for
Helicobacter pylori in patients with recurrent aphthous stomatitis.", Oral
Dis. 2005 Jan;11(1):22-6.
Entrez PubMed
3. Kilmartin CM. "Dental implications of Helicobacter pylori".,
J Can Dent Assoc.
2002 Sep;68(8):489-93.
Entrez PubMed
4. Thongprasom K, Youngnak P, Aneksuk V., "Hematologic abnormalities
in recurrent oral ulceration.", Southeast Asian J Trop Med Public Health.
2002 Dec;33(4):872-7.
Entrez PubMed
5. Ogura M, Yamamoto T, Morita M, Watanabe T.. "A case-control study
on food intake of patients with recurrent aphthous stomatitis.", Oral Surg
Oral Med Oral Pathol Oral Radiol Endod. 2001 Jan;91(1):45-9.
Entrez PubMed
6. Weusten BL, van de Wiel A., "Aphthous ulcers and vitamin B12
deficiency", Neth J Med. 1998 Oct;53(4):172-5.
Entrez PubMed
7. Barnadas MA, Remacha A, Condomines J, de Moragas JM., "[Hematologic
deficiencies in patients with recurrent oral aphthae]", Med Clin (Barc).
1997 Jun 14;109(3):85-7.
Entrez PubMed
8. Haisraeli-Shalish M, Livneh A, Katz J, Doolman R, Sela BA.,
"Recurrent aphthous stomatitis and thiamine deficiency", Oral Surg Oral Med
Oral Pathol Oral Radiol Endod. 1996 Dec;82(6):634-6.
Entrez PubMed
9. Nolan A, McIntosh WB, Allam BF, Lamey PJ., "Recurrent aphthous
ulceration: vitamin B1, B2 and B6 status and response to replacement
therapy.", J Oral Pathol Med. 1991 Sep;20(8):389-91.
Entrez PubMed
10. Wray D., "Gluten-sensitive recurrent aphthous stomatitis", .Dig
Dis Sci. 1981 Aug;26(8):737-40.
Entrez PubMed
11. Wray D, Ferguson MM, Hutcheon WA, Dagg JH., "Nutritional deficiencies in
recurrent aphthae.", J Oral Pathol. 1978;7(6):418-23.
Entrez PubMed
12. Correll RW, Wescott WB, Jensen JL., "Recurring, painful oral ulcers", J
Am Dent Assoc. 1981 Sep;103(3):497-8.
Entrez PubMed
13. Hay KD, Reade PC., "The use of an elimination diet in the treatment of
recurrent aphthous ulceration of the oral cavity.", Oral Surg Oral Med Oral
Pathol. 1984 May;57(5):504-7.
Entrez PubMed
14.Nolan A, Lamey PJ, Milligan KA, Forsyth A, "Recurrent aphthous ulceration
and food sensitivity.", J Oral Pathol Med. 1991 Nov;20(10):473-5.
Entrez PubMed
15.Wilson CW., "Food sensitivities, taste changes, aphthous ulcers and
atopic symptoms in allergic disease."Ann Allergy. 1980 May;44(5):302-7.
Entrez PubMed
16. Bays RA, Hamerlinck F, Cormane RH., "Immunoglobulin-bearing
lymphocytes and polymorphonuclear leucocytes in recurrent aphthous ulcers in
man.", Arch Oral Biol. 1977;22(2):147-53.
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