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PDR Health on Prebiotics

Getting enough good bacteria in your belly? - Today: Food - MSNBC.com

Butyrate for Colon Health

Search for more probiotics - look under acidophilus/probiotics in the category box

 


Probiotics: Nature's Internal Healers


 


The Probiotic Solution: Nature's Best-Kept Secret for Radiant Health

 


The Consumer's Guide To Probiotics: The Complete Source Book


Probiotics for allergy prevention: alternative medicine: an evidence-based approach.(Clinical Rounds) : An article from: Internal Medicine News


 


Probiotics: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References

 


Acidophilus and Colon Health: The Natural Way to Prevent Disease


Probiotics may prevent antibiotic-related diarrhea.(Digestive Disorders) : An article from: Family Practice News


How to Stop Candida & Other Yeast Conditions in Their Tracks

 


Candida and Candidiasis

 


Conquering Yeast Infections The Non Drug Solution For Men And Women


Pathogenic fungi (yeasts)

Species identification and virulence attributes of Saccharomyces boulardii (nom. inval.).

Ban GM Probiotics

Bifidobacterial Lipoglycan as a New Cause for False-Positive Platelia Aspergillus ELISA Reactivity -- Mennink-Kersten et al. 43 (8): 3925 -- Journal of Clinical Microbiology

Probiotics and Prebiotics

Consumption of prebiotic inulin enriched with olig...[Br J Nutr. 2007] - has minor effects on immune system in cancer patients

Our Fruitless War on Germs | Newsweek To Your Health | Newsweek.com


 

Probiotics

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*Sal-Free
Probiotics refer to a group of beneficial bacteria that are part of the normal gut flora.  The type and number of bacteria play an important role in determining health and disease.  There are over 500 species of microflora in the gut which normally remain in balance with each other.  The use of antibiotics, birth control pills, sugar, diarrhea, gastrointestinal ph and a number of other factors can cause this delicate balance to be destroyed and start one on the road to disease.

Health conditions that have been reported to benefit from the use of probiotics include diarrhea, gastroenteritis, irritable bowel syndrome, and inflammatory bowel disease (Crohn's disease and ulcerative colitis), cancer, depressed immune function, inadequate lactase digestion, infant allergies, failure-to-thrive, hyperlipidemia, hepatic diseases, Helicobacter pylori infections, genitourinary tract infections and others.6  Antibiotic-associated diarrhea and Clostridium difficile disease (CDD) are also helped by probiotics.12  Probiotics are highly recommended for (candida) yeast infections which would include thrush, systemic yeast infection or vaginal yeast infection.

Probiotics are protective of the gastrointestinal tract because they help to keep the good bacteria in balance with the bad bacteria.   An article published in Clinical Gastroenterology, noted that a review of the literature indicated that the main function of probiotics is to reinforce the intestinal mucosal barrier against detrimental agents.5    


Some of the strains that are often used in supplements are acidophilus and bifidobacteria but there are many others.  Many quality products include what are called FOS (fructooligosaccharides) because they feed the good bacteria and help to rebalance your bacteria quicker..

Fructooligosaccharides
*Sal-Free
Fructooliosaccharides, also called FOS for short, are often included in probiotic products because they feed the good bacteria and allow them to thrive and grow while reducing the number of bad bacteria in the colon.  One study indicates that fructooligosaccharides significantly increase calcium and magnesium absorption as well.8  

Inulin is a fructooligosaccharide derived from Chicory root and other natural sources. it also has a very low glycemic index, it is suitable for many people who are on restricted diets, such as sugar-free or low carbohydrate. Add it to your favorite beverage or food or add it to kefir. Its taste is comparable to sugar and can be used as a sugar substitute.



Inulin Prebiotic FOS Vegetarian, Now Foods, 8 oz *Sal-Free


For more information:
PDR- Health Fructo-oligosaccharides


Kefir and Yogurt
*Sal-Free
In addition to taking probiotics in tablet form, eating yogurt and kefir are excellent ways to get beneficial flora.

Both yogurt and kefir cleanse your digestive system and help you digest food.  Yogurt can be eaten everyday to help feed beneficial bacteria that already exists in your body and kefir can be used to re-colonize your body with beneficial bacteria.  Kefir is said to have some beneficial strains of bacteria that yogurt does not have. Kefir is pre-digested so is not a problem for those who have problems digesting milk.

Dom's Kefir in-site
Make your own kefir with kefir starters Yahoo Groups : Kefir_making
International Kefir grains database

Lactoferrin
*Sal-Free
Lactoferrin is a protien found in milk and other secretions.  It is a natural peptide derived from whey that has powerful probiotic properties.  When fed to adult animals and human infants, lactoferrin showed a dramatic increase in good micro flora—such as bifidus—and a decrease in bad bacteria, such as E. coli, streptococcus, clostridium and others.


Other Benefits:
Anti-microbial
Anti-viral
Immune modulation

Anti-oxidant
Protection against endotoxins

PDRHealth Lactoferrin

Saccharomyces Boulardii
*Sal-Free
Saccharomyces Boulardii is a yeast that is probiotic in action and is considered  non-pathogenic.  Studies have verified that it is useful for treatment of diarrhea and that it is safe (see caution below for immune compromised individuals).   It is used to prevent diarrhea associated with antibiotic use.

S. boulardii improves the immune system defenses, digestion, and absorption of nutrients. It also helps regulate gene expression and protein synthesis.9    In animal studies, S. boulardii protects against diarrhea and enterocolitis induced by a variety of enteric pathogens, including C. difficile.  In human studies, S. boulardii treatment reduced the risk of subsequent relapse in patients with a history of multiple episodes of C. difficile. 10  In another animal study, S. Boulardii inhibits the Escherichia coli endotoxin.11

One study notes that it's possible that some strains of Saccharomyces Boulardii could become pathogenic so they recommend caution  in immunocompromised patients until further study is undertaken.7


Safety
Keep in mind that there are many strains of bacteria that are considered probiotic and not all of them have been extensively studied, but based on many years of use all over the world, probiotics in general are considered safe.

Most probiotic strains of bacteria are non-pathogenic (non-disease causing) however caution should be used in those who have conditions that seriously compromise their immune system such as in someone with aids or in newborns who are seriously ill.

Infection with Lactobacilli or Bifidobacteria is rare.17,18 Saccharomyces Boulardii could become pathogenic so caution  should be used in patients with compromised immune systems.7
 

Antibiotic Use 
The bacterial community in the gastrointestinal tract protects us against potential pathogens by a mechanism called 'colonization resistance'.  When the gastrointestinal tract is colonized with enough beneficial bacteria, it prevents the pathogenic, disease causing bacteria from taking hold. 

Along with doing their job of killing disease causing bacteria, antibiotics often disrupt the delicate balance of intestinal flora by killing bacteria that is needed in order to keep the colon healthy.  A double-blind, placebo-controlled trial showed that probiotic supplementation modulates the response of the intestinal microflora to the effects of antibiotic therapy.1  Another radomized controlled trial showed that probiotics prevented an imbalance in the number of disease causing bacteria (
Bacteriodes fragilis)  during antibiotic use.4  

Saccharomyces Boulardii is a specific probiotic that is used to prevent diarrhea associated with antibiotic use but many other probiotic are helpful as well.12

Candida (Candidiasis)
Candida is a particular grouping of fungi that cause infections such as thrush, vaginal yeast infections and systemic yeast infections.

 Candida lives in the human body and usually causes no problems because our normal gut flora (probiotics) and our immune system keep it under control.  When we take antibiotics, eat sugar, have poor digestion or do other things that cause our flora to become unbalanced and/or we have a compromised immune system we often get an overgrowth of candida. 

A systemic candida infection can cause a huge list of symptoms that can mimic many other illnesses.  Recommended treatment usually includes a change in diet, re-balancing gut flora with the use of probiotics and rebalancing candida by reducing it's population through the use of supplements or drugs.

Some M.D.'s do not believe that candida is a problem for most people unless they have a seriously compromised immune system however most alternative doctors such as Naturopaths understand the danger and will properly treat a systemic yeast infection.

Diarrhea
According to the CDC, Bacteriodes fragilis is often associated with diarrheal diseases.  In a  radomized controlled trial,  probiotics prevented ecological disturbances in the numbers of intestinal Bacteroides fragilis group species during clindamycin (a frequently used antibiotic) administration.4 63% of French pediatricians prescribe l-acidophilus for their patients who have diarrhea.2

Even when one is not currently using antibiotics, an unbalanced gut flora can cause diarrhea that can be reduced or eliminated with the use of probiotics.  It can take up to a year or more to re-balance your gut flora if severely unbalanced but most people notice fewer episodes of diarrhea within the first 2 months if not sooner. 

Detoxification
Acidophilus may help to detoxify harmful substances by restoring "friendly" bacteria in your body. Friendly bacteria bind with some unwanted substances, causing them to be excreted.
For additional information on detoxification see:
Detoxification

Digestion
Probiotics can be helpful in restoring digestion because they foster healthy gastro-intestinal function.

H-Pylori
Several studies show that lactobacilli inhibits or kills H. pylori.  In vivo models show that pre-treatment with a probiotic can prevent H. pylori and/or markedly reduced an existing infection.3
Probiotics and Prebiotics in Gastrointestinal Disorders


Immune System

An animal study concluded that probiotics stimulate production of natural antibodies.13  Production of the natural virus-fighter, interferon, is decreased in fatigued athletes, but it can be restored to normal levels with Lactobacillus acidophilus according to a study in the British Journal of Sports Medicine.14

 Regulation gastrointestinal flora by the use of pre- and probiotics, offers the possibility to influence the development of mucosal, and also systemic immunity.15


Irritable Bowel Syndrome
Probiotics have been shown to alleviate symptoms in irritable bowel syndrome.19, 20,21

One study concluded that the alleviation of symptoms may be associated with immune modulation due to normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine.19

Mouth Sores
Some mouth sores respond well to powdered acidophilus applied directly to the sore and allowed to dissolve.  In some cases, pain can be greatly relieved in a short time using fresh, live, powdered bacteria in the mouth.

Thrush
Thrush is a type of yeast (fungal) infection that is caused by candida.  It often occurs in small children and the elderly but can occur in anyone with a compromised immune system or who has been using antibiotics or other things that cause their gut flora to become unbalanced or the candida fungus to grow.  Thrush can be helped with the use of a good probiotic.  You can buy products designed especially for children or the elderly.

If you have thrush, you likely have a candidia overgrowth and should consider treatment options for candida.


Recurrent Urinary Tract Infections (UTIs)
Many studies and clinical trials have generated encouraging results for the safety and effectiveness of using probiotics to prevent recurrent urinary tract infections in women, especially certain lactobacillus strains. 

Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 (previously called L. fermentum RC-14) were the most effective. L. casei shirota and L. crispatus CTV-05 have also shown efficacy in some studies. L. rhamnosus GG did not appear to be quite as effective in the prevention of UTIs.16


Vitamin K
Probiotics help to synthesize vitamin K.  Vitamin K is needed in order for the blood to clot.  Deficiencies of vitamin K can occur with antibiotic use.

Yeast Infection
A vaginal yeast infection, thrush and a systemic yeast infection are all caused by candida albicans, a type of fungus.  All three can be helped with the rebalancing of gut flora through the use of probiotics. Not only is it helpful to take a good probiotic with FOS internally but one can sometimes get immediate relief of some symptoms by applying the powder directly on the affected area.   

Some foods that contain beneficial bacteria are:
Yogurt
buttermilk
cheese
kefir
miso
sauerkraut


Warnings:
 
If your flora is seriously out of balance you can have diarrhea when first taking probiotics.  You can also have a detoxification reaction.  Start out slowly and work your way up to the recommended dosage.  Take any probiotics as far away from antibiotic type medications or the friendly bacteria will be killed along with the bad.

Before taking any supplements, consult with your health care provider.    This information is not intended to diagnose, treat, cure or prevent any disease.  We do not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein.


References
1. Madden JA, Plummer SF, Tang J, Garaiova I, Plummer NT, Herbison M, Hunter JO, Shimada T, Cheng L, Shirakawa T., "Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study.", Int Immunopharmacol. 2005 Jun;5(6):1091-7.
Entrez PubMed

2.Uhlen S, Toursel F, Gottrand F; Association francaise de pediatrie ambulatoire., [Treatment of acute diarrhea: prescription patterns by private practice pediatricians], Arch Pediatr. 2004 Aug;11(8):903-7.
Entrez PubMed

3. Hamilton-Miller JM., "The role of probiotics in the treatment and prevention of Helicobacter pylori infection.", Int J Antimicrob Agents. 2003 Oct;22(4):360-6.
Entrez PubMed

4. Sullivan A, Barkholt L, Nord CE.,  "Lactobacillus acidophilus, Bifidobacterium lactis and Lactobacillus F19 prevent antibiotic-associated ecological disturbances of Bacteroides fragilis in the intestine.", Antimicrob Chemother. 2003 Aug;52(2):308-11. Epub 2003 Jul 15.
Entrez PubMed

5. Fioramonti J, Theodorou V, Bueno L., " Probiotics: what are they? What are their effects on gut physiology?", Best Pract Res Clin Gastroenterol. 2003 Oct;17(5):711-24.
Entrez PubMed

6.  Brown AC, Valiere A., "Probiotics and medical nutrition therapy.", Nutr Clin Care. 2004 Apr-Jun;7(2):56-68.
Entrez PubMed


7. Michael J. McCullough, Karl V. Clemons, John H. McCusker, and David A. Stevens, "Species Identification and Virulence Attributes of Saccharomyces boulardii (nom. inval.)", Journal of Clinical Microbiology, September 1998, p. 2613-2617, Vol. 36, No. 9
0095-1137/98/

Species Identification and Virulence Attributes of Saccharomyces boulardii (nom. inval.) -- McCullough et al. 36 (9): 2613 -- Journal of Clinical Microbiology

8.  Ohta A, Ohtsuki M, Baba S, Adachi T, Sakata T, Sakaguchi E., "Calcium and magnesium absorption from the colon and rectum are increased in rats fed fructooligosaccharides.", J Nutr. 1995 Sep;125(9):2417-24.
Entrez PubMed

9.  Buts JP, De Keyser N., "Effects of Saccharomyces boulardii on intestinal mucosa",
Dig Dis Sci. 2006 Aug;51(8):1485-92. Epub 2006 Jul 13.
Entrez PubMed

10.  Amir Qamar, Samer Aboudola, Michel Warny, Pierre Michetti, Charalabos Pothoulakis, J. Thomas LaMont, and Ciarán P. Kelly*, "Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficile Toxin A in Mice", Infect Immun. 2001 April; 69(4): 2762–2765.
doi: 10.1128/IAI.69.4.2762-2765.2001.
Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficile Toxin A in Mice

11.  Buts JP, Dekeyser N, Stilmant C, Delem E, Smets F, Sokal E., "Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation",  Pediatr Res. 2006 Jul;60(1):24-9. Epub 2006 May 11.
Entrez PubMed

12.  McFarland LV., "Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease.",  Am J Gastroenterol. 2006 Apr;101(4):812-22.
Entrez PubMed

13. Haghighi HR, Gong J, Gyles CL, Hayes MA, Zhou H, Sanei B, Chambers JR, Sharif S., "Probiotics stimulate production of natural antibodies in chickens.", Clin Vaccine Immunol. 2006 Sep;13(9):975-80
Entrez PubMed

14.  R L Clancy1, M Gleeson2, A Cox2, R Callister1, M Dorrington2, C D’Este1, G Pang1, D Pyne3, P Fricker3 and A Henriksson, "Reversal in fatigued athletes of a defect in interferon secretion after administration of Lactobacillus acidophilus", British Journal of Sports Medicine 2006;40:351-354; doi:10.1136/bjsm.2005.024364
Reversal in fatigued athletes of a defect in interferon {gamma} secretion after administration of Lactobacillus acidophilus -- Clancy et al. 40 (4): 351 -- British Journal of Sports Medicine

15.  Bauer E, Williams BA, Smidt H, Verstegen MW, Mosenthin R., "Influence of the gastrointestinal microbiota on development of the immune system in young animals.",  Curr Issues Intest Microbiol. 2006 Sep;7(2):35-51.
Entrez PubMed

16.  Falagas ME, Betsi GI, Tokas T, Athanasiou S., "Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies.", Drugs. 2006;66(9):1253-61
Entrez PubMed

17.Arrel Olano,1 Jimmy Chua,2 Suzanne Schroeder,2 Afaf Minari,3 Margaret La Salvia,2 and Gerri Hall2*, "Weissella confusa (Basonym: Lactobacillus confusus) Bacteremia: a Case Report", J Clin Microbiol. 2001 April; 39(4): 1604–1607. doi: 10.1128/JCM.39.4.1604-1607.2001.
Weissella confusa (Basonym: Lactobacillus confusus) Bacteremia: a Case Report

18.  S. P. Borriello, W. P Hammes, W. Holzapfel, P. Marteau, J. Schrezenmeir, M. Vaara, and V. Valtonen, "Safety of Probiotics That Contain Lactobacilli or Bifidobacteria", Clinical Infectious Diseases, volume 36 (2003), pages 775–780
The University of Chicago Press - doi:10.1086/368080

19. O'Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, O'Sullivan GC, Kiely B, Collins JK, Shanahan F, Quigley EM.,  "Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.", Gastroenterology. 2005 Mar;128(3):541-51.
Entrez PubMed

20. Whorwell PJ, Altringer L, Morel J, Bond Y, Charbonneau D, O'Mahony L, Kiely B, Shanahan F, Quigley EM.,  "Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome.", Am J Gastroenterol. 2006 Jul;101(7):1581-90
Entrez PubMed

21.  Kim HJ, Vazquez Roque MI, Camilleri M, Stephens D, Burton DD, Baxter K, Thomforde G, Zinsmeister AR., "A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating.", Neurogastroenterol Motil. 2005 Oct;17(5):687-96
Entrez PubMed



 

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